Police say a ring of steel will be placed around Hyndburn as part of a high profile crackdown on travelling criminals.
The lockdown, which will run until the end of July, will focus on reducing road casualties and disrupting crime such as drug supply, theft and the disposal of stolen property.
Officers will be on the lookout for motorists committing road traffic offences, such as speeding, using a mobile phone while driving and having no tax or insurance.
Teams will carry out the same tactics in Blackburn with Darwen and the Ribble Valley.
Chief Inspector Damian Darcy said routes known to be used by criminals will be focused on.
He said: "We know there are criminals who live outside Lancashire, who are prepared to travel into the county to commit crime. My message to them is simple - if you come to East Lancashire to commit offences you will be relentlessly pursued and will be put before the courts."
Anyone with information or concerns about crime can contact police on 0845 1 25 35 45 or Crimestoppers anonymously on 0800 555 111.