Council leader Peter Britcliffe has called on the government to make mephedrone an illegal drug.
The appeal comes just days after two teenagers from Scunthorpe were believed to have died after taking the drug.
In December last year Hyndburn police warned youngsters against taking the drug following the death of a 14-year-old girl in Bristol.
One month later Hyndburn councillors called for the drug to be made illegal after fears that youngsters in the borough were using it emerged.
It is believed that it has become popular on the UK club scene in recent months.
In a letter addressed to the Home Secretary, Councillor Peter Britcliffe demands a ban on the sale of the recreational drug – known as meow meow, bubble or legal high – throughout the United Kingdom.
He also expressed concerns at the affect the drug was having across Hyndburn and East Lancashire.
"I would like the government to obtain and implement a ban on the sale of this drug throughout the United Kingdom," said Councillor Britcliffe in his letter to the Home Secretary, MP Alan Johnson.
He added: "No drug is safe and little is known about the long term effects.
"Sadly, because of its use in our area we expect it is readily available throughout most towns and cities in the north west of England and the UK."
Imported from China, cheap and widely available over the internet, mephedrone is usually found in a white/ yellowish powder and snorted or taken as a pill.
Drug and alcohol services have warned that mephedrone use can result in severe nose bleeds, nose burns, hallucinations, blood circulation problems, rashes, anxiety/paranoia, fits and delusions.
Last year Observer reporter Vanessa Cornall bought the drug over the internet as part of a news investigation into how dangerous it is.
Mount Carmel High School headteacher Katrina Ryan thinks the government should seriously consider banning the sale of mephodrone.
She said: "I entirely support the council leader on this. This is a very dangerous drug which should be made illegal."
Councillor Britcliffe also sent a copy of the letter to the all party parliamentary drugs misuse group, which educates members of both Houses of Parliament on such issues.
He added: "I will also be approaching other local authorities to seek their support in tackling this problem and prohibiting the legal sale of the drug. I would welcome the opportunity to discuss with your officials any areas where Hyndburn Borough Council may assist in taking this work forward."
On Wednesday, the Home Office said it will receive advice from the Advisory Council on the Misuse of Drugs on March 29.
Mephodrone is currently legal to buy and be in possession of the powder, but against the law to sell, supply or advertise the powder for human consumption under the Medicines Act.