A ‘wintry’ mix of snow and sleet has hit the borough for a second successive morning.
Police warned of treacherous rush-hour conditions and visibility on motorways and roads.
There are currently ‘hazardous’ driving conditions in both directions on the M66 between the A56 Edenfield Bypass/ A680 Bolton Road North / A56 Wood Lane / A676 Bolton Road North (Ramsbottom Junction) and J3 (Hollins).
Lancashire Police has also issued a warning to drivers across the borough and those travelling along Grane Road.
A spokesperson said: “It is treacherous at the moment due to snow.”
The North West Motorway Police said the M65, M66 and A56 are all being affected by snow.
A Met Office weather warning remains in place.
A spokesman said an area of rain, sleet and snow would last well into Friday morning.
The Met Office said: “Please be aware of the risk of difficult driving conditions and disruption to transport.”
No school closures have been reported.
Bus companies Transdev and Rosso said all their services are running as normal.
Earlier, the Met Office issued a yellow warning of snow for the region, and warned of potential disruption due to the possibility of snow settling in the early hours of Friday morning, particularly on higher ground.
Martin Dunwell, countywide highways manager for Lancashire County Council, said they have 49 frontline gritters in action.
He said: "The cold snap we've experienced this week has kept our gritting teams busy, and we're well-prepared to deal with whatever the weather brings.
"We would ask drivers to be aware of the potential for icy conditions overnight and on Friday morning.
"Even when a road has been gritted, it can remain icy until the movement of traffic has worked the salt in and made it take effect, so it's vital to drive according to the conditions and consider that there could be icy patches.
"If you can see that the conditions are icy, it's worth considering whether your journey is essential."